Abstract: With the continuous improvement of the penetration rate of new energy, the uncertain factors of power grid operation such as power balance and power market increase, and the randomness and volatility of new energy output will cause more complex power grid loss mechanism and loss reduction problems, which makes the power grid line loss management face severe challenges. Taking transmission network and distribution network as the research object, this paper studies the influence factors of high permeability new energy access on its line loss, and puts forward loss reduction measures and relevant suggestions.