Abstract: The previous 10 kV distribution network construction and maintenance work often led to frequent power outages, long time and other problems. Starting from the technical principle of 10 kV distribution network uninterrupted power operation, this paper analyzes several common operation methods and applications of 10 kV distribution network uninterrupted power operation. Through specific application case analysis, this paper discusses the specific methods and advantages of 10 kV distribution network uninterrupted power operation technology application, which can effectively solve the disadvantages of the traditional 10 kV distribution network uninterrupted power operation method, and has good economy and reliability. In order to fully guarantee the application effect of 10 kV distribution network uninterrupted power operation method, To achieve the goal of uninterrupted power operation, the safeguard measures are proposed to optimize the management mode, enhance the safety awareness and improve the management level.