Abstract: The space vector pulse width modulation (SVPWM) method applied to the neutral point clamped (NPC) three-level inverter cannot effectively reduce the common mode voltage (CMV) due to the zero vector participating in the modulation or rolling optimization, and the operation time is long. To solve the above problems, a model predictive control algorithm considering neutral point potential, switching frequency and common mode voltage is proposed in this paper. Firstly, the discrete mathematical prediction model of load current and neutral point potential of NPC three-level inverter is established. Then, the multi constraint objective functions of neutral point potential, switching frequency and CMV are constructed, and the optimal vector is selected to act on NPC three-level inverter, reducing common mode voltage and running time. Finally, the simulation model is built on matlab/simulink platform, and the performance of the algorithm is verified.