Abstract: With the continuous promotion of building a new power system, the power grid has gradually developed into a huge dimensional system with complex structure, various equipment and complex technology. It faces great challenges in operation and analysis. The traditional analysis method based solely on physical modeling has been difficult to meet the requirements of complex coupled system of power grid. Artificial intelligence technology supported by advanced sensor technology and computer technology provides a new technical means for power grid operation and control. The challenges faced by the application of artificial intelligence in the field of power grid operation are analyzed. The scenarios and modes of integrated application of artificial intelligence in the field of power grid operation are studied and summarized. It provides a reference for the fusion application of artificial intelligence technology in the field of power grid operation in the future.