Abstract: Starting from the current situation of 110 kV Meinan station 2# main transformer, this paper analyzes the precautions in the maintenance and replacement of switches in the transformer, and forms a scientific and standardized construction scheme for the maintenance and replacement of switches in the transformer based on this. At the same time, for the risk factors of switch maintenance and replacement in 110 kV Meinan station 2# main transformer, carry out full cycle safety management and control, so as to provide corresponding reference for substation construction management and control.